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肿瘤生长与转移依赖于其新生的脉管系统为其提供充足的营养并带走其代谢产物，而这些脉管系统生长主要受到血管生长因子的调控，而在这些调控因子中血管内皮生长因子(vascular endothelial growth factor，VEGF)家族及其受体与胃癌的侵袭转移联系最为紧密。 VEGF高表达涉及胃癌的诊断、治疗及预后等诸多方面。医学的发展为胃癌治疗带来了新的希望，随之针对VEGF家族的靶向治疗也是近些年研究的热点问题。未来是否能够通过针对该家族成员的治疗途径来达到治愈胃癌的目的仍是一个值得研究的问题。,Tumor growth and metastasis depend on its new vascular system to provide adequate nutrition and take away its metabolites, the vasculature growth mainly be regulated and controled by vascular growth factors, vascular endothelial growth factor and its receptor family most closely associated with the invasion and metastasis of gastric cancer in the control factor.High VEGF expression in the diagnosis,treatment and prognosis of gastric cancer,and many other aspects.The development of medicine in the treatment of gastric cancer has brought new hope, then the target therapy aimed at VEGF family is also a hot issue of research in recent years.Whether can pass for the members of the family’s future treatment way to achieve the purpose of cure the cancer of the stomach is still a problem worth studying.