作者综述了近年来有关器官移植病人的临床药物动力学(以下简称药动学)文献219篇。作者首先指出由于环孢素(cyclosporin)的使用及其与皮质激素和硫唑嘌呤的联用,加之采用单克隆抗体对抗T_3淋巴细胞,使器官移植病人和移植物的存活时间显著延长。存活一年以上的肾移植占95%,心脏移植占78%,肝脏移植占70%。在药物吸收方面移植成功的病人与正常人相似。 The authors reviewed 219 articles about the clinical pharmacokinetics (hereinafter referred to as pharmacokinetics) of organ transplant patients in recent years. The authors first point out that due to the use of cyclosporin and its combination with corticosteroids and azathioprine, and the use of monoclonal antibodies against T_3 lymphocytes, the survival time of organ transplant patients and grafts is significantly prolonged. Survival of more than one year accounted for 95% of kidney transplant, heart transplant 78%, liver transplantation accounted for 70%. Patients who successfully transplant in the area of ​​drug absorption are similar to normal people.