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为了寻找三九感冒灵颗粒中三叉苦茎的替代资源,通过硅胶、凝胶、反相柱色谱和半制备HPLC对三叉苦的叶进行分离纯化,利用光谱学手段结合理化性质鉴定其结构。从三叉苦的叶子中分离得到10个化合物,经多种波谱学方法鉴定其结构分别为4-hydroxy-4,7-dimethyl-1-tetralone(1),(6R,7E)-4,7-megastigmadien-3,9-dione(2),4-megastigmen-3,9-dione(3),芒柄花素(4),大豆苷元(5),千层纸素A(6),汉黄芩素(7),5,7-二羟基-3,4’-二甲氧基黄酮(8),N-反式香豆酰基酪胺(9),对羟基桂皮酸(10)。所有化合物均为首次从该种植物中分离得到。结果表明三叉苦茎和叶的化学成分存在较大差异。
In order to find an alternative resource of Sanji yiganling granule, the leaves of Euonymus japonicus were isolated and purified by silica gel, gel, reverse phase column chromatography and semi-preparative HPLC. Their structures were identified by spectroscopic methods and physical and chemical properties. Ten compounds were isolated from the leaves of Tripterygium, and their structures were identified by various spectroscopic methods as 4-hydroxy-4,7-dimethyl-1-tetralone (1), (6R, 7E) megastigmadien-3,9-dione (2), 4-megastigmen-3,9-dione (3), formononetin (4), daidzein (5), melatonin A (7), 5,7-dihydroxy-3,4’-dimethoxyflavone (8), N-transcoumastamyl (9), and p-hydroxycinnamic acid (10). All compounds were isolated from this plant for the first time. The results show that there is a big difference between the chemical constituents of the stems and leaves of the trifal.