糖尿病妊娠胎儿先天畸形发生率为6％～15％,其中心血管畸形占总数的40％～50％。由于糖尿病孕妇产生先天畸形儿的风险增加,围产儿致病率和死亡率增高,有必要进行产前诊断。为对胰岛素依赖型糖尿病孕妇群体行综合性产前诊断以检测胎儿先天畸形的临床价值作出评价,分析了289例胰岛素依赖型糖尿病孕妇及其新生儿的数据。所有孕妇于早孕或中孕初期测血红蛋白A_1,结果以其占总血红蛋白的百分率表示,正常值为4.5％～8.0％。孕15～18周时测母血清AFP值,大于中位数的1.5倍者为升高。孕18周时作B超观察胎儿心 The incidence of fetal congenital malformations in pregnancy is 6% to 15%, of which cardiovascular malformations account for 40% to 50% of the total. Due to increased risk of congenital malformations in pregnant women with diabetes, the incidence of perinatal morbidity and mortality increased, the need for prenatal diagnosis. To evaluate the clinical value of comprehensive prenatal diagnosis of fetuses with congenital diabetes mellitus to detect fetal congenital malformations, the data of 289 pregnant women with insulin dependent diabetes mellitus and their newborns were analyzed. All pregnant women in early pregnancy or early pregnancy measured hemoglobin A_1, the results of its total hemoglobin percentage, said the normal value of 4.5% to 8.0%. Measured 15-18 weeks pregnant maternal serum AFP value, greater than 1.5 times the median for the increase. 18 weeks pregnant for B-observation fetal heart