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目的:考察5个厂家注射用盐酸甲氯芬酯在输液中的稳定性,为临床用药安全、有效提供可靠依据。方法:将5个厂家生产的注射用盐酸甲氯芬酯分别溶于4种不同输液中,于0,0.5,1,2,3.5,6.5,8,24 h,分别测定其pH;采用紫外分光光度法测定含量,并观察其外观变化。结果:24 h内5个不同厂家的注射用盐酸甲氯芬酯含量、pH均无显著差异(P>0.05);外观均无变化。结论:5个厂家的注射用盐酸甲氯芬酯在4种输液中,24 h内稳定性无显著差异。
OBJECTIVE: To investigate the stability of meclofenoxate hydrochloride for infusion in five manufacturers for the purpose of providing safe and effective clinical medication. Methods: Meclofenoxate hydrochloride for injection was dissolved in 4 different infusion solutions respectively at 5 days, 0, 0.5, 1, 2, 3.5, 6.5, 8 and 24 h, respectively. The content was determined by spectrophotometry and the change of appearance was observed. Results: There was no significant difference in the content and pH of meclofenoxate hydrochloride in five different manufacturers within 24 h (P> 0.05). There was no change in appearance. CONCLUSION: There was no significant difference in the stability of meclofenoxate hydrochloride for injection among the four infusion solutions within 24 h.