血栓性血小板减少性紫癜(TTP)系一少见的危重综合征。临床上以微血管病性溶血性贫血、血小板减少性紫癜、神经系统症状、肾脏损害和发热为特征。近10余年来,国外对TTP发病机理的研究一直十分活跃,治疗也有很大进展。本文就国外近年来研究近况综述如下。发病机理 TTP发病机理目前尚未完全明了,且争论颇多,可归纳为下例几种观点: 1.血管壁原发性损害学说。早年,Alsehu1e等认为TTP的原发病变是由于血管壁的损害。其依据是电镜观察发现,患者病变的毛细血管内皮下有纤维蛋白透明物质沉积,因而认 Thrombotic thrombocytopenic purpura (TTP) is a rare critically ill syndrome. Clinically, microangiopathic hemolytic anemia, thrombocytopenic purpura, neurological symptoms, kidney damage and fever are characterized. In the past 10 years, the research on the pathogenesis of TTP in foreign countries has been very active, and treatment has made great progress. This article reviews the recent progress of foreign countries in recent years are as follows. Pathogenesis The pathogenesis of TTP is not yet fully understood, and a lot of controversy, can be summarized as follows several views: 1. Primary damage theory of vascular wall. Early years, Alsehu1e so that the primary lesion of TTP is due to damage to the vessel wall. It is based on the observation by electron microscopy found that lesions of the lesion capillaries fibrin transparent material deposition, which recognize