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目的探讨HCMV、ADV和HBV抗原在IGA肾病患者肾组织中的表达及临床意义。方法选取我院2009年1月至2012年12月46例IgA肾病患者,以免疫组织化学措施对IgA病症肾活检组织给予HCMV、ADV以及HBV抗原表达检测。结果 HCMV主要表达于肾小管及肾小球;ADV主要表达于肾小管上皮细胞当中,在肾小球中表达较少,在肾间质中也有微量表达。HCMV临床表达和肾小球、肾小管间质遭受损坏程度具有正相关性。HBsAg于肾小管上皮细胞表达,少量于肾小球、肾间质表达。HBsAg临床表达和肾小球、肾小管间质损坏程度不具有相关性。结论 HCMV、ADV和HBV表达都和IgA肾病出现、发展具相关性。
Objective To investigate the expression and clinical significance of HCMV, ADV and HBV antigens in renal tissues of IGA nephropathy patients. Methods 46 patients with IgA nephropathy in our hospital from January 2009 to December 2012 were enrolled. HCMV, ADV and HBV antigen expression were detected by immunohistochemistry in renal biopsy of IgA. Results HCMV was mainly expressed in renal tubules and glomeruli. ADV was mainly expressed in renal tubular epithelial cells, with less expression in glomeruli and slight expression in renal interstitium. HCMV clinical expression and glomerular and tubulointerstitial damage suffered a positive correlation. HBsAg expression in renal tubular epithelial cells, a small amount of expression in glomerular and renal interstitium. HBsAg clinical expression and glomerular, tubulointerstitial damage is not related to the degree. Conclusion The expression of HCMV, ADV and HBV are associated with the occurrence and development of IgA nephropathy.