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miRNA(microRNA)是一族由22~25个核苷酸组成的非编码RNA小分子,它通过与靶mRNA的3′-非编码区以碱基互补配对的方式结合,实现对靶基因转录后水平的降解或抑制.最新研究表明,miRNA与鼻咽癌中EBV,LMP1,信号转导通路,肿瘤相关基因网络,细胞有丝分裂,肿瘤血管生成和侵袭转移密切相关.因此,探索miRNA与鼻咽癌发生发展之间的关系,有助于加深对其发病机制的认识,也将为临床诊断和治疗提供新的启示与依据.
MicroRNAs (miRNAs) are small non-coding RNA molecules consisting of 22-25 nucleotides that bind to the 3’-noncoding region of a target mRNA in a base-pairing manner to achieve post-transcriptional level of the target gene The latest research shows that miRNA is closely related to EBV, LMP1, signal transduction pathway, tumor-related gene network, cell mitosis, tumor angiogenesis and invasion and metastasis in nasopharyngeal carcinoma.Therefore, to explore the miRNA and nasopharyngeal carcinoma The relationship between development and help to deepen their understanding of the pathogenesis, but also for clinical diagnosis and treatment provide new inspiration and basis.