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目的探讨人乳头状瘤病毒(HPV)-16、18型、单纯疱疹病毒2型(HSV-2)和巨细胞病毒(CMV)感染与宫颈癌的关系。方法对66例宫颈癌、58例宫颈上皮内瘤样变(CIN)、20例慢性宫颈炎患者宫颈活检组织用聚合酶链反应方法检测HPV-16、18型、HSV-2和CMV感染情况。结果 HPV-16、18型、HSV-2、CMV阳性率从宫颈癌组到慢性宫颈炎组均有递减趋势;HPV-16型病毒的阳性例数中宫颈癌组分别与CIN组比较、慢性宫颈炎组比较差异有统计学意义(c2=28.714,c2=55.907,P<0.05),CIN组与慢性宫颈炎组比较差异有统计学意义(c2=11.507,P<0.05);HPV-18、HSV-2和CMV病毒的阳性例数中,宫颈癌组分别与CIN组、CIN组与慢性宫颈炎组比较差异无统计学意义(c2=1.758,c2=0.000,c2=0.937,P>0.05);在宫颈癌组中单独或合并HPV-16、HPV-18、HSV-2、CMV的感染率明显高于非宫颈癌组。结论HPV在引起宫颈癌的作用是主要的,HSV-2、CMV合并感染可能会增加患病的危险性,可将性传播疾病患者作为宫颈癌风险人群进行防癌筛查,以提高早期诊断和早期治疗率。
Objective To investigate the relationship between human papillomavirus (HPV) -16,18, herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV) infection and cervical cancer. Methods The HPV-16, 18, HSV-2 and CMV infections were detected by polymerase chain reaction in 66 cases of cervical cancer, 58 cases of cervical intraepithelial neoplasia (CIN) and 20 cases of chronic cervicitis. Results The positive rates of HPV-16, HPV-12, HSV-2 and CMV all decreased from cervical cancer group to chronic cervicitis group. The positive rate of HPV-16 in cervical cancer group was significantly higher than that in CIN group There was significant difference between the two groups (c2 = 28.714, c2 = 55.907, P <0.05). There was significant difference between CIN group and chronic cervicitis group (c2 = 11.507, P <0.05) -2 and CMV, there was no significant difference between CIN group and chronic cervicitis group in cervical cancer group (c2 = 1.758, c2 = 0.000, c2 = 0.937, P> 0.05). The infection rate of HPV-16, HPV-18, HSV-2 and CMV in cervical cancer group was significantly higher than that in non-cervical cancer group. Conclusions HPV is the main cause of cervical cancer. Combined infection with HSV-2 and CMV may increase the risk of SARS, and may use STD patients as cancer prevention screening for cervical cancer patients in order to improve early diagnosis and Early treatment rate.