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目的:观察消糖益肾合剂配合西药治疗早期糖尿病肾病的临床疗效。方法:将糖尿病肾病患者58例随机分为治疗组32例和对照组26例。对照组予现代医学常规治疗,治疗组在对照组治疗的基础上,予中药复方消糖益肾合剂口服。1月为1疗程,1疗程后观察疗效。观察2组患者的尿微量白蛋白、血液流变学指标和临床证候改善情况。结果:治疗组和对照组治疗前后尿微量白蛋白分别比较,差异均有非常显著性意义(P<0.01)。2组治疗后尿微量白蛋白及2组间差值分别比较,差异均有非常显著性意义(P<0.01)。治疗组治疗前后全血高切、中切和低切黏度以及血浆黏度比较,差异均有非常显著性意义(P<0.01);对照组治疗前后全血高切、中切和低切黏度以及血浆黏度比较,差异均有显著性意义(P<0.05)。2组治疗后全血高切、中切和低切黏度以及血浆黏度比较,差异均有非常显著性意义(P<0.01),治疗组的疗效明显优于对照组。总有效率治疗组为100%,对照组为88.5%,2组比较,差异有显著性意义(P<0.05)。结论:消糖益肾合剂配合西药治疗早期糖尿病肾病疗效肯定。
Objective: To observe the clinical efficacy of Xiaoshisanyisheng Mixture combined with western medicine in the treatment of early diabetic nephropathy. Methods: 58 patients with diabetic nephropathy were randomly divided into treatment group (32 cases) and control group (26 cases). The control group was given routine treatment of modern medicine. On the basis of the treatment of the control group, the treatment group was orally administered with the Chinese medicine compound Xiaoshishen Shenshe Mixture. January for a course of treatment, after a course of treatment to observe the effect. Urine microalbuminuria, hemorrheological indexes and clinical symptoms were observed in two groups. Results: There were significant differences in urinary albumin before and after treatment between the treatment group and the control group (P <0.01). Urine microalbuminuria after treatment and differences between the two groups were compared, the differences were significant (P <0.01). Before and after treatment in the treatment group, whole blood high-cut, medium and low shear viscosity and plasma viscosity, the differences were significant (P <0.01); control group before and after whole blood high-cut, medium and low shear viscosity and plasma Viscosity comparison, the difference was significant (P <0.05). The difference between the two groups in the whole blood high-cut, medium and low cut-point viscosity and the plasma viscosity had a significant difference (P <0.01). The curative effect of the treatment group was obviously better than that of the control group. The total effective rate was 100% in the treatment group and 88.5% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: Xiaoshisanyishenkang combined with Western medicine for the treatment of early diabetic nephropathy certainly.