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背景与目的:细胞增殖与代谢相关的肿瘤标志物在上颌窦癌的研究较少。本研究旨在探讨晚期上颌窦鳞癌谷胱甘肽S-转移酶-π(glutathioneS-transferaseπ,GST-π)和增殖细胞核抗原(proliferatingcellnuclearantigen,PCNA)的表达与预后的关系。方法:选取晚期上颌窦鳞癌组织54例,上颌窦良性肿瘤组织29例,正常鼻腔粘膜组织20例。免疫组化法检测标本组织中GST-π和PCNA的表达。Kaplan-Meier法评估晚期上颌窦鳞癌GST-π和PCNA的表达水平与预后的关系;Cox回归模型进行多因素预后分析。结果:上颌窦鳞癌组织中的GST-π和PCNA高表达率显著高于良性肿瘤组织和正常组织(74.1%vs.89.6%和15.0%,P<0.01;79.6%vs.3.4%和0,P<0.01)。单因素生存分析表明GST-π低表达组与高表达组的5年生存率分别为34.5%与21.2%,差别有统计学意义(P=0.025),PCNA低表达组与高表达组的5年生存率分别为18.0%与27.0%,差别无统计学意义(P=0.890)。多因素生存分析显示GST-π的表达(P=0.039,OR>1)对生存率的影响有统计学意义。结论:GST-π表达是影响晚期上颌窦鳞癌预后的独立因素;PCNA表达水平与生存无关。
BACKGROUND & AIM: There are few studies on cell proliferation and metabolism related tumor markers in maxillary sinus cancer. This study aimed to investigate the relationship between the expression of GST-π and proliferating cell nuclear antigen (PCNA) and the prognosis of advanced maxillary sinus squamous cell carcinoma. Methods: 54 cases of advanced squamous cell carcinoma of the maxillary sinus, 29 cases of maxillary sinus benign tumor and 20 cases of normal nasal mucosa were selected. Immunohistochemistry was used to detect the expression of GST-π and PCNA in the specimens. Kaplan-Meier method was used to assess the relationship between the expression of GST-π and PCNA in advanced squamous cell carcinoma of the maxillary sinus and its prognosis. Cox regression model was used to analyze the prognosis of patients with advanced maxillary sinus cancer. RESULTS: The high expression rates of GST-π and PCNA in squamous cell carcinoma of the maxillary sinus were significantly higher than those in benign tumor and normal tissues (74.1% vs.89.6% vs 15.0%, P <0.01; 79.6% vs.3.4% vs0.4% P <0.01). Univariate survival analysis showed that the 5-year survival rates of GST-πlow expression group and high expression group were 34.5% and21.2%, respectively, with significant difference (P = 0.025), low PCNA expression group and high expression group The survival rates were 18.0% and 27.0% respectively, with no significant difference (P = 0.890). Multivariate survival analysis showed that the expression of GST-π (P = 0.039, OR> 1) had a significant effect on the survival rate. Conclusion: The expression of GST-π is an independent factor affecting the prognosis of advanced maxillary sinus squamous cell carcinoma. The expression level of PCNA has no relation with survival.