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目的:探讨血清炎性因子C-反应蛋白(CRP)、白细胞介素(IL-6)水平与老年冠心病患者伴焦虑情绪的相关性。方法:收集老年冠心病患者64例,进行焦虑自评量表(SAS)评分,根据评分结果将其分为冠心病不伴焦虑情绪组、冠心病伴焦虑情绪组,测定所有研究对象的血清CRP、IL-6水平。结果:64例患者中男性36例(56.25%),女性28例(43.75%),伴有焦虑情绪35例(47.45%),其中男性有15例(42.9%),女性20例(57.1%),男女冠心病患者伴焦虑情绪差异有统计学意义(P<0.05)。伴有焦虑情绪的血清CRP、IL-6水平与不伴有焦虑情绪的差异有统计学意义(P<0.05)。血清炎症因子水平CRP、IL-6与焦虑程度呈正相关。结论:伴有焦虑情绪的老年冠心病患者血清CRP、IL-6水平升高,且与焦虑程度呈正相关。
Objective: To investigate the relationship between serum inflammatory cytokine C-reactive protein (CRP), interleukin (IL-6) and anxiety in elderly patients with coronary heart disease. Methods: Sixty-four elderly patients with coronary heart disease (CHD) were collected and scored for anxiety (SAS). According to the scores, they were divided into two groups: CHD without anxiety group and CHD with anxiety group. All subjects were tested for serum CRP , IL-6 levels. Results: There were 36 males (56.25%), 28 females (43.75%) and 35 anxiety (47.45%) in 64 patients, of which 15 males (42.9%) and 20 females (57.1%), There was significant difference between men and women with coronary heart disease and anxiety (P <0.05). The levels of CRP and IL-6 in serum associated with anxiety were significantly different from those without anxiety (P <0.05). Serum levels of inflammatory cytokines CRP, IL-6 and anxiety levels were positively correlated. Conclusion: The levels of serum CRP and IL-6 in elderly patients with anxiety associated with anxiety are positively correlated with the degree of anxiety.