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目的探讨持续性透析(MHD)患者矿物质和骨代谢紊乱与高敏C反应蛋白(hs-CRP)水平的关系。方法选择2015年10月~2016年10月在我院血透室进行MHD的78例患者,测定其hs-CRP水平以及矿物质和骨代谢相关指标[血钙(Ca)、血磷(P)和甲状旁腺素(PTH)],统计患者的透析充分性,采用多元线性回归分析hs-CRP水平与Ca、P和PTH的关系。结果 78例患者中,24例达到了美国肾脏病患者生存质量指南(K/DNOQI)推荐的电解质标准,达标率为30.77%(24/78)。达标组与未达标组间的hs-CRP水平比较,差异有统计学意义(P<0.05)。hsCRP水平与血P水平成正相关,与血Ca和PTH水平无相关性。结论 MHD患者矿物质和骨代谢紊乱与hs-CRP水平高度相关,血P为hs-CRP水平增高的危险因素。
Objective To investigate the relationship between mineralosis and bone metabolism disorders and high-sensitivity C-reactive protein (hs-CRP) levels in patients with persistent dialysis (MHD). Methods Seventy eight patients with MHD who underwent MHD in our hospital from October 2015 to October 2016 were enrolled in this study. The levels of hs-CRP and the indexes of mineral and bone metabolism [Ca, P] And parathyroid hormone (PTH)]. The dialysis adequacy was calculated. The relationship between hs-CRP and Ca, P and PTH was analyzed by multivariate linear regression. Results Of the 78 patients, 24 achieved the recommended electrolyte standard of K / DNOQI in American Society of Nephrology with the compliance rate of 30.77% (24/78). The hs-CRP levels between the standard group and the non-standard group were significantly different (P <0.05). There was a positive correlation between hsCRP level and blood P level but no correlation with serum Ca and PTH level. Conclusion The disorder of mineral and bone metabolism in MHD patients is highly correlated with the level of hs-CRP. Blood P is a risk factor for the increased hs-CRP level.