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急进高原胃肠动力紊乱是高原胃肠应激反应的主要表现之一,腹胀、恶心、呕吐、腹泻、食欲减退等是其最突出的临床症状,目前有关其的研究多集中于临床及部分基础研究上,但在探讨有关高原胃肠动力紊乱形成机制的细胞分子生物学领域的研究则少见报道。而大量研究指出,慢波起源细胞Cajal间质细胞在胃肠动力调控中具有重要作用,并成为的研究的热点,那么Cajal间质细胞是否同样在急进高原胃肠动力紊乱中发挥同样重要的作用,这不但对从细胞分子生物学角度来解释急进高原胃肠动力紊乱的机制有着重要的意义,而且还可以对未来的临床干预提供新的思路。因此,本文拟对Cajal间质细胞在急进高原胃肠动力紊乱中的潜在作用作一综述。
Hypertensive gastrointestinal motility disorder is one of the main manifestations of gastrointestinal stress response in plateau. Abdominal distension, nausea, vomiting, diarrhea and loss of appetite are the most prominent clinical symptoms. At present, most researches focus on clinical and partial basis However, few studies have been reported on the field of molecular biology of the pathogenesis of gastrointestinal motility disorder at the plateau. However, a large number of studies have pointed out that Cajal stromal cells of slow-wave origin cells play an important role in the regulation of gastrointestinal motility and become hot spots for research. Whether Cajal interstitial cells also plays an equally important role in the steepness of gastrointestinal motility in acute plateau disease This not only has great significance in explaining the mechanisms of acute gastrointestinal motility disorder from the perspective of cellular molecular biology, but also can provide new ideas for future clinical intervention. Therefore, this article intends to review the potential role of Cajal interstitial cells in the steepness of gastrointestinal motility disorders at high altitude.