Restoring nervous system structure and function using tissue engineered living scaffolds

来源 :中国神经再生研究(英文版) | 被引量 : 0次 | 上传用户:zhengwei2
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following ner-vous system injury or neurodegenerative disease. Disconnection of axon pathways – the long-distance ifbers connecting specialized regions of the central nervous system or relaying peripheral signals – is a common feature of many neurological disorders and injury. However, functional axonal regenera-tion rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engi-neered “living scaffolds”, which are preformed three-dimensional constructs consisting of living neural cells in a deifned, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration – mimicking key developmental mechanisms– or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal clusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in preclinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.
其他文献
期刊
期刊
期刊
本文从分析工程建设行业存在的主要瓶颈入手,描述了工程建设行业全流程一体化架构,并详细介绍了工程建设行业全流程一体化的核心特征,最后从协同设计平台的发展阶段和计算机
本刊讯 2001年12月27日,虽是寒冬,但河南省计量测试研究所春意盎然.国家质量监督检验检疫总局李长江局长和蒲长城副局长以及刘平均司长、纪正昆司长、刘兆彬司长在河南省政府