目的：研究盐藻β胡萝卜素（βｃａｒｏｔｅｎｅｆｒｏｍＤｕｎａｌｉｅｌａｓａｌｉｎａ，βＣＤＳ）致突变及抗突变作用．方法：用体外人淋巴细胞微核和染色体畸变检测，研究了βＣＤＳ对γ射线和丝裂霉素（Ｍｉｔ）诱变作用的影响．结果：βＣＤＳ１－３０ｍｇ·Ｌ－１对人淋巴细胞无致突变性，但能抑制γ射线诱发的微核形成和Ｍｉｔ诱发的染色体畸变．当合成β胡萝卜素与天然β胡萝卜素油（βＣＤＳ成份之一）按８０∶２７５混合后，拮抗了前者的遗传毒性，并使两者的抗突变作用得到增强．结论：βＣＤＳ是一种抗突变成份 Objective: To study the mutagenesis and anti-mutation effect of β-carotenefromDunalielasalina (βCDS). Methods: In vitro human lymphocyte micronucleus and chromosome aberration detection, β-CDS γ-ray and mitomycin (Mit) mutagenic effects. Results: β-CDS1-30mg · L-1 on human lymphocytes without mutagenicity, but can inhibit γ-ray-induced micronucleus formation and Mit induced chromosome aberration. When β-carotene and natural β-carotene oil (one of the β-CDS components) were mixed at 80:275, they were antagonistic to the former genotoxicity and their anti-mutagenic effects were enhanced. Conclusion: βCDS is an anti-mutation ingredient