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目的探讨小牛血清去蛋白提取物灌肠用于临床防治宫颈癌患者放射性直肠炎的效果,为临床指导用药提供依据。方法按照随机数字表法将60例原发宫颈癌初治拟行放疗患者分为对照组(小牛血清去蛋白提取物静脉滴注)与观察组(小牛血清去蛋白提取物灌肠),各30例,均治疗2个月。比较两组患者治疗后急性放射性直肠炎分级(按照美国放射治疗肿瘤组(RTOG)/欧洲癌症治疗组织机构(EORTC)标准和疼痛情况(按照疼痛数字评价表实施评价),采用KPS评分评价两组患者治疗前后生活质量情况,统计两组临床疗效。结果观察组患者治疗后急性放射性直肠炎分级、疼痛评分分别为(1.30±0.51)级、(2.20±0.81)分,明显低于对照组(2.10±0.70)级、(3.71±1.10)分,P<0.05;观察组治疗后KPS评分(89.14±10.25)分,明显高于对照组(76.96±8.47)分,P<0.05。观察组治疗总有效率63.33%,明显高于对照组的36.67%,P<0.05。治疗期间均未产生任何不良反应。结论小牛血清去蛋白提取物灌肠用于临床防治宫颈癌患者放射性直肠炎具有显著效果,可有效提高患者生活质量。
Objective To investigate the effect of deproteinized bovine serum extract on clinical prevention and treatment of radiation proctitis in patients with cervical cancer and provide basis for clinical guidance. Methods According to the random number table method, 60 cases of primary cervical cancer patients undergoing radiotherapy were divided into control group (intravenous drip of deproteinized calf serum) and observation group (deproteinised extract of calf serum) 30 cases were treated for 2 months. Acute radiation proctitis grading (RTOR / EORTC criteria) and pain conditions (evaluated according to the Pain Number Evaluation Table) were compared between the two groups, and KPS scores were used to evaluate both groups Results After treatment, the scores of acute radiation proctitis and pain in the observation group were (1.30 ± 0.51) and (2.20 ± 0.81) points respectively, which were significantly lower than those in the control group (2.10 ± 0.70), (3.71 ± 1.10) points, P <0.05; KPS score of the observation group after treatment was 89.14 ± 10.25, which was significantly higher than that of the control group (76.96 ± 8.47), P <0.05. The effective rate was 63.33%, which was significantly higher than that of the control group (36.67%, P <0.05) .There was no adverse reaction during the treatment.Conclusion The bovine serum albumin extract enema has a significant effect in the prevention and treatment of radiation proctitis in patients with cervical cancer Effectively improve the quality of life of patients.