【摘 要】
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This study assessed concentrations of Ca2+, Mg2+, Cu2+ and Zn2+ in blood serum and spinal cord tissues, as well as the possible mechanisms by which propofol may
【机 构】
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Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medic
论文部分内容阅读
This study assessed concentrations of Ca2+, Mg2+, Cu2+ and Zn2+ in blood serum and spinal cord tissues, as well as the possible mechanisms by which propofol may protect spinal cord tissues during ischemia/reperfusion injury. With prolonged duration of ischemia/reperfusion injury, serum Ca2+ and Cu2+ concentrations gradually increased, but Mg 2+ and Zn2+ concentrations gradually decreased. Seven days after spinal cord injury, changes in Ca2+, Mg2+, Cu2+ and Zn2+ concentrations were significant. After 7 days of reperfusion, changes in the concentrations of Ca2+, Mg2+, Cu2+ and Zn2+ in spinal cord homogenates were consistent with those in the serum. After propofol treatment, no significant changes in Ca2+, Mg2+, Cu2+ and Zn2+ concentrations in serum and spinal cord homogenates were noted during ischemia/reperfusion injury. These findings suggest that propofol exerts protective effects against spinal cord injury by stabilizing or recovering metal ion balance in ischemic regions.
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