论文部分内容阅读
为研究新生儿接种血源乙型肝炎 (乙肝 )疫苗的远期效果和探究加强免疫的必要性 ,对上海市原南市区 1986年出生时接种血源乙肝疫苗的儿童 ,至少隔年随访 1次 ,采血检测乙肝病毒表面抗原 (HBsAg)、乙肝病毒表面抗体(抗 HBs)、乙肝病毒核心抗体 (抗 HBc)。结果显示 :16年间HBsAg阳性率在 0 4 6 %～ 0 98%之间 ,平均 0 6 3%(95 %可信区间为 0 39%～ 0 83% ) ,大大低于免疫前本底对照和外对照 ,而且无随免疫时间的延长而升高的趋势。与外对照相比 ,血源乙肝疫苗的远期保护效果为 82 0 6 % (95 %可信区间为 73 4 5 %～ 91 83% )。提示新生儿血源乙肝疫苗全程免疫后 16年无加强免疫的必要。
To study the long-term effect of neonatal vaccination on blood-borne Hepatitis B (HBV) vaccine and to explore the necessity of boosting immunity, children born at HeNan city of Shanghai in 1986 who were born with blood-borne hepatitis B vaccine should be followed up at least once a year, Blood samples were collected for detection of hepatitis B virus surface antigen (HBsAg), hepatitis B virus surface antibody (anti-HBs) and hepatitis B virus core antibody (anti-HBc). The results showed that the positive rate of HBsAg in 16 years was between 0 4 6% and 0 98%, with an average of 0 6 3% (95% confidence interval 0 39% -0 83%), which was much lower than that before immunization External control, but with the extension of immunization time and the trend of rising. Compared with the external control, the long-term protective effect of blood-borne hepatitis B vaccine was 82% (95% confidence interval: 73.45% -91.83%). Prompt Neonates Hematological Hepatitis B Vaccine 16 Years After Complete Immunization Needed to Strengthen Immunization.