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目前的研究表明,晚期糖基化终产物(AGEs)通过多种途径引起神经组织结构、代谢和功能的改变,在糖尿病周围神经病的发病中具有重要作用。本文就AGEs的产生、结构以及造成糖尿病周围神经病的可能机制作一综述。
Recent studies have shown that advanced glycation end products (AGEs) cause changes in the structure, metabolism and function of nerve tissue through various pathways and play an important role in the pathogenesis of diabetic peripheral neuropathy. This article reviews the generation and structure of AGEs and the possible mechanisms that contribute to diabetic peripheral neuropathy.