肝细胞癌(肝癌,HCC)是由病毒、化学致癌物等多病因作用,因癌基因或癌相关基因激活、抗癌基因失活或胚胎期某些酶基因重新复活等诸多因素引起肝细胞生长失控而致癌变[1],经启动、促进、演变多阶段的发病过程,其中基因的调控表达、多种生长因子的活性等均与肝癌的发生发展密切相关[2]。胰岛素样 Hepatocellular carcinoma (HCC) is caused by multiple etiological factors such as viruses and chemical carcinogens. Hepatocyte growth is caused by many factors such as activation of oncogenes or cancer-related genes, inactivation of anti-oncogenes, or resurgence of certain enzyme genes in the embryo Out of control and carcinogenesis [1], after starting, promoting, evolving multi-stage pathogenesis, including gene regulation and expression, a variety of growth factor activities are closely related with the occurrence and development of liver cancer [2]. Insulin-like