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本文旨在研究大黄对烧伤的疗效及其作用机理。 2 6只Balb/c小鼠 ,制成烧伤模型 ,随机分成大黄汤剂治疗组和对照组。专人盲法测定肠道灌洗液中总蛋白和球蛋白 (G) ,同时送小肠病理学检查。结果发现 :①治疗组小鼠存活率较对照组有所提高 ;②病理显示对照组 ,小肠绒毛变平 ,有破损现象 ,而用了大黄的小鼠肠粘膜也有破损 ,但可见更多的完整的肠绒毛存在 ,且肠绒毛较对照组高 ;③治疗组小鼠肠道灌洗液中 ,总蛋白和球蛋白的含量均明显高于对照组 ,其均数分别为 3 72g/L和 1 5 7g/L (P <0 0 5 )及 4 12g/L和 2 13g/L (P <0 0 5 )。提示严重烧伤可导致肠粘膜屏障损害。而大黄有促肠道球蛋白分泌作用 ,及减轻肠道形态学改变的作用 ,从而降低烧伤的死亡率
This article aims to study the efficacy and mechanism of rhubarb on burns. A total of 6 Balb/c mice were made into burn models and randomly divided into treatment group and control group. Specialists blinded the determination of total protein and globulin (G) in intestinal lavage fluid and sent small intestinal histopathological examinations. The results showed that: 1 The survival rate of the mice in the treatment group was higher than that of the control group; 2 The pathological findings showed that the villi of the small intestine were flat and damaged, while the mice with the rhubarb were also damaged, but more intact The intestinal villi was present, and the intestinal villi were higher than the control group; 3 The content of total protein and globulin in the intestinal lavage fluid of the treated group was significantly higher than that of the control group, and the mean numbers were 3 72 g/L and 1 respectively. 5 7g/L (P <0 0 5) and 4 12g/L and 2 13g/L (P <0 0 5). It is suggested that severe burns can cause damage to the intestinal mucosal barrier. Rhubarb has the effect of promoting the secretion of intestinal globulin and reducing the morphological changes of the intestine, thereby reducing the mortality rate of burns.