麻风病是一个古老的疾病,其发病机制仍未清楚,预防和治疗进展都不大。近年来,许多学者从免疫学角度进行研究,初步认为麻风病是慢性感染引起的免疫紊乱。有资料表明,麻风病人皮损的恢复,主要是细胞免疫起关键作用,但瘤型麻风病人有细胞免疫缺陷。Hiess报告在瘤型麻风病人血清中有抑制细胞免疫因子。Skinsness报告瘤型麻风病人巨噬细胞中缺乏β葡萄糖醛酸酶,并推测这种缺陷可能是先天性的。 Leprosy is an ancient disease, the pathogenesis is still not clear, prevention and treatment of little progress. In recent years, many scholars from the immunological point of view, initially considered that leprosy is a chronic infection caused by immune disorders. Data show that the recovery of leprosy skin lesions, mainly cellular immunity plays a key role, but the leprosy patients have cellular immune deficiency. Hiess reports suppression of cellular immune factors in the serum of leprous leprosy patients. Skinsness reported lack of beta-glucuronidase in macrophages from leprous leprous patients and speculated that this defect may be congenital.