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目的 探讨外周血中CD4 + CD4 5RA+ T细胞和CD4 + CD4 5RO+ T细胞在结直肠癌中的变化及其临床意义。方法 采用流式细胞术检测 6 0例结直肠癌患者手术前、术后 1个月和 3个月时 ,外周血的CD4 + T细胞、CD4 + CD4 5RA+ T细胞和CD4 + CD4 5RO+ T细胞的比例。选取健康查体人群 10例作为对照。结果 结直肠癌患者的CD4 + T细胞与健康人群相比无差异。CD4 + CD4 5RO+ T细胞比例明显增高 ,术后有显著下降 ,DukesA、B期患者尤其明显 ;而CD4 + CD4 5RA+ T细胞比例正好相反。结论 CD4 + CD4 5RA+ T细胞和CD4 + CD4 5RO+ T细胞在肿瘤免疫中起重要作用 ,其表达同结直肠癌的分期和预后有密切关系。
Objective To investigate the changes of CD4 + CD4 + 5RA + T cells and CD4 + CD4 + 5RO + T cells in peripheral blood and their clinical significance. Methods Peripheral blood CD4 + T cells, CD4 + CD4 + 5RA + T cells and CD4 + CD4 + 5RO + T cells were detected by flow cytometry in 60 patients with colorectal cancer before operation, 1 month and 3 months after operation proportion. Ten healthy people were selected as control. Results There was no difference in CD4 + T cells between patients with colorectal cancer and healthy people. The proportion of CD4 + CD4 + 5RO + T cells was significantly increased after operation, with a significant decrease after operation, especially in Dukes A and B patients, while the proportion of CD4 + CD4 + 5RA + T cells was opposite. Conclusion CD4 + CD4 + 5RA + T cells and CD4 + CD4 + 5RO + T cells play an important role in tumor immunity. The expression of CD4 + CD4 + 5R0 + T cells is closely related to the staging and prognosis of colorectal cancer.