Objective: This study aimed to explore the perceptions of parents of children with autism spectrum disorder (ASD) and their coping strategies.Methods: The data of the study was collected using face-to-face semi-structured interviews.The participants were purposefully selected from the three schools in Mpumalanga Province because they had children diagnosed with ASD and data was analyzed using thematic content analysis.In this study,primary caregivers were selected.In the end,12 women were interviewed,and the data saturation was reached.Ethical considerations and measures to ensure trustworthiness were carried out throughout the study.Results: The findings revealed two themes: caregivers’ understanding and misconceptions of ASD and coping mechanisms used in dealing challenges of caring for a child with ASD;and five subthemes: lack of knowledge,cultural beliefs,prayer,strong support system,and acceptance.Conclusion: Based on the findings,more awareness campaigns should be done on ASD to increase parents’ understanding of the condition.Understanding the cultural beliefs of parents regarding ASD may assist health care professionals in developing care practices that are accepted in their culture,and may enhance parents’ coping skills.