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目的研究梅毒患者细胞免疫功能状态。方法运用流式细胞仪,分析了23例梅毒患者的外周血中T淋巴细胞免疫表型的特点及其与疗效间的关系。同时应用酶联免疫吸附法测定了血清可溶性白介素2受体(sIL-2R)的水平变化。结果23例梅毒患者外周血中总T、TH、NK细胞及TH/TS的比值均低于正常对照组(P<0.01或P<0.05),而Ts的比例及sIL-2R水平则显著高于正常对照组(P<0.01)。经驱梅治疗后3个月,血清阴转患者及未阴转患者分为两组。无论是治疗前还是治疗后,血清未阴转患者细胞免疫功能均较血清阴转患者更低。结论梅毒患者的细胞免疫功能受到不同程度的损伤,损伤程度与疗效密切相关。
Objective To study the status of cellular immune function in syphilis patients. Methods The characteristics of T lymphocyte immunophenotype in peripheral blood of 23 patients with syphilis were analyzed by flow cytometry and their relationship with the therapeutic effect. Serum levels of soluble interleukin 2 receptor (sIL-2R) were measured by enzyme-linked immunosorbent assay (ELISA). Results The ratio of total T, TH, NK cells and TH / TS in 23 patients with syphilis was lower than that of the normal control group (P <0.01 or P <0.05), but the ratio of Ts and the level of sIL-2R were significantly higher Normal control group (P <0.01). Three months after the treatment of flooding, patients with seronegative and non-overcast patients were divided into two groups. No matter before treatment or after treatment, the cellular immune function of patients with undeveloped serum is lower than that of patients with serum negative conversion. Conclusion The cellular immune function of syphilis patients is damaged to some extent. The degree of injury is closely related to the curative effect.