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背景与目的:人乳头状瘤病毒(human papilloma virus,HPV)作为食管癌发生重要的环境因素备受许多学者的关注,但其相关性未得到一致性公认,尤其对于高发的新疆哈萨克族食管癌。本研究探讨HPV16感染与新疆哈萨克族食管癌发生、发展的相关性。方法:采用半巢式聚合酶链反应(polymerase chain reaction,PCR)技术检测100例新疆哈萨克族食管癌患者癌组织和100例新疆哈萨克族正常人食管正常黏膜组织HPV16E6的感染情况。结果:新疆哈萨克族食管癌患者HPV16E6感染率为46%,明显高于新疆哈萨克族正常人群感染率的22%(P<0.001,OR=3.020);HPV16E6感染与新疆哈萨克族食管癌患者的发病年龄、性别、肿瘤生长部位、淋巴转移、分化程度无明显相关性(P均>0.05)。结论:HPV16E6感染与新疆哈萨克族食管癌发病密切相关,是其发病的重要因素之一。
BACKGROUND & OBJECTIVE: Human papilloma virus (HPV), as an important environmental factor in esophageal cancer, has attracted the attention of many scholars but its correlation has not been recognized universally. Especially for the high incidence of Xinjiang Kazakh esophageal cancer . This study was to investigate the relationship between HPV16 infection and the occurrence and development of esophageal cancer in Xinjiang Kazak. Methods: The infection of HPV16E6 in 100 cases of esophageal cancer tissue from Xinjiang Kazakh and 100 cases of normal esophageal mucosa from Kazak of Xinjiang was detected by polymerase chain reaction (PCR). Results: The prevalence of HPV16E6 was 46% in Kazakh Kazakh esophageal cancer patients, which was significantly higher than that of normal Kazakh population in Xinjiang (P <0.001, OR = 3.020). The HPV16E6 infection was associated with the age at onset of Kazakh Kazakh esophageal cancer , Sex, tumor growth site, lymph node metastasis and differentiation degree (P> 0.05). Conclusion: HPV16E6 infection is closely related to the incidence of esophageal cancer in Xinjiang Kazak, which is one of the important factors in the pathogenesis of esophageal cancer.