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目的研究Ⅱ糖尿病人使用维库溴铵后对神经肌肉阻滞的时间效应。方法随机选择需全麻手术的病人30倒,ASAⅠ～Ⅱ级。DM组(n=15)为糖尿病组;C组(n=15)为非糖尿病组。采用异丙酚—异氟醚静吸复合麻醉,用四个成串刺激检测两组病人能够引起最大反应(TO)的平均最大刺激量,静注维库溴铵0.1mg/kg后T_1、T_2、T_3、T_4恢复时间。结果DM组,平均最大刺激量明显高于C组((50.5±14.1 VS 33.4±6.1)MA P<0.01);给维库溴铵0.1mg/kg后,DM组T1和T4恢复时间明显长于C组(T1(37.5±15.2 VS 25.7±7.6)min,P=0.01;T4(63.4±22.7VS 42.5±11.5)min,P=0.01)。给维库溴铵80—120分钟后,糖尿病组T1/T0明显低于时照组(P<0.05)。结论T_1、T_2、T_3、T_4恢复时间,糖尿病组明显长于非糖尿病组;糖尿痛患者最大刺激量明显高于非糖尿病患者:给维库溴铵后,糖尿病患者阻滞时间明显延长。
Objective To study the time effect of verapamil on neuromuscular blockade in type 2 diabetic patients. Methods Randomly selected 30 patients required general anesthesia surgery, ASA Ⅰ ~ Ⅱ level. DM group (n = 15) was diabetic group; group C (n = 15) was non-diabetic group. With propofol - isoflurane inhalation anesthesia combined with four series of stimulation to detect the two groups of patients can cause maximum response (TO) of the average maximum stimulation, intravenous vecuronium 0.1mg / kg after T_1, T_2 , T_3, T_4 recovery time. Results The mean maximal stimulation in DM group was significantly higher than that in C group (50.5 ± 14.1 vs 33.4 ± 6.1, MA P <0.01). After vecuronium 0.1 mg / kg, T1 and T4 recovery time in DM group was significantly longer than that in C group Group (T1 (37.5 ± 15.2 vs 25.7 ± 7.6) min, P = 0.01; T4 (63.4 ± 22.7 vs 42.5 ± 11.5) min, P = 0.01). After 80-120 minutes of vecuronium, the T1 / T0 of diabetic group was significantly lower than that of the control group (P <0.05). Conclusion The recovery time of T_1, T_2, T_3 and T_4 was significantly longer in diabetic group than in non-diabetic group. The maximal stimulation in patients with diabetic pain was significantly higher than that in non-diabetic patients. After vecuronium treatment, the blocking time in diabetic patients was significantly longer.