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目的探讨淋巴结转移个数、转移度及转移区域数与中晚期胸段食管鳞癌(ESCC)预后的关系。方法回顾性分析2002年1月~2006年12月在我院行胸段ESCC根治术的339例中晚期胸段ESCC患者的临床资料。结果全组共清除淋巴结4 767枚,淋巴结转移445枚,淋巴结转移度9.34%,每例平均清除淋巴结14.06枚;339例中晚期胸段ESCC的1、3、5 a生存率分别为80.49%、41.94%、23.12%,其中有淋巴结转移与无淋巴结转移的1、3、5 a生存率差异显著(P<0.01);淋巴结转移数量、转移度及转移区域数与中晚期胸段ESCC的预后呈负相关(P<0.01)。结论淋巴结转移数量、转移度及转移区域数是影响中晚期胸段ESCC预后的重要因素。
Objective To investigate the relationship between the number of lymph node metastasis, the degree of metastasis and the number of metastatic lymph nodes and the prognosis of advanced thoracic esophageal squamous cell carcinoma (ESCC). Methods The clinical data of 339 patients with advanced thoracic ESCC undergoing thoracic esophagectomy in our hospital from January 2002 to December 2006 were analyzed retrospectively. Results A total of 4 767 lymph nodes, 445 lymph node metastases, 9.34% lymph node metastases and 14.06 lymph nodes were removed in each group. The 1,3,5-year survival rates of 339 patients with advanced thoracic ESCC were 80.49% 41.94% and 23.12%, respectively. There was a significant difference in the survival rates between 1 and 3 years (P <0.01). The number of lymph node metastasis, the degree of metastasis and the number of metastatic lymph nodes and the prognosis of advanced thoracic ESCC Negative correlation (P <0.01). Conclusions The number of lymph node metastasis, the degree of metastasis and the number of metastatic lymph nodes are the important factors affecting the prognosis of advanced thoracic ESCC.