肺炎球菌感染是世界范围内引起死亡的重要原因之一，且是肺炎、脑膜炎、中耳炎的主要病因。估计全世界每年至少有100万人死于肺炎球菌性肺炎（’）、在美国，肺炎球菌感染所致死亡人数高于任何其它可免疫预防的感染性疾病；在亚洲，肺炎球菌感染则是某些国家重要的发病和死亡原 Pneumococcal infection is one of the leading causes of death worldwide, and is the leading cause of pneumonia, meningitis and otitis media. It is estimated that at least one million people die of pneumococcal pneumonia each year worldwide (’). In the United States, pneumococcal infections cause more deaths than any other immunocompromising infectious disease; in Asia, pneumococcal infections are some Some countries important morbidity and mortality of the original