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目的探讨脂微球前列腺素E1(lipo-PGE1)对糖尿病肾病(DN)内皮细胞功能、纤溶活性及尿蛋白的影响。方法86例DN早期患者随机分为两组:对照组(常规治疗组)46例,观察组(应用lipo-PGE1)41例,治疗8w,观察两组病人在治疗前后血清内皮素(ET-1)、纤溶酶原激活抑制物-1(PAI-1)活性和尿蛋白量等指标的变化。结果对照组ET-1水平及尿蛋白有轻微下降,但无统计学意义,观察组ET-1水平明显下降(P<0.01),PAI-1活性明显降低(P<0.01),尿蛋白量也有明显下降(P<0.01)。结论lipo-PGE1对DN内皮细胞功能有明显的改善作用,并可以提高纤溶活性,抑制肾脏蛋白排除作用。
Objective To investigate the effect of lipo-PGE1 on endothelial cell function, fibrinolytic activity and urinary protein in diabetic nephropathy (DN). Methods Eighty-six patients with early DN were randomly divided into two groups: control group (routine treatment group), control group (41 cases) and lipo-PGE1 group (41 cases) for 8 weeks. ET- ), Plasminogen activator inhibitor-1 (PAI-1) activity and urine protein content and other indicators. Results The levels of ET-1 and urinary protein decreased slightly in the control group, but the levels of ET-1 in the observation group were significantly decreased (P <0.01) and the activity of PAI-1 was significantly decreased (P <0.01) Significantly decreased (P <0.01). Conclusion lipo-PGE1 can significantly improve the function of DN endothelial cells, and can increase fibrinolytic activity and inhibit renal protein exclusion.