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目的分析血清淀粉酶A蛋白(SAA)、中性粒细胞表面抗原CD64及降钙素原(PCT)在新生儿败血症早期诊断中的价值。方法回顾性分析2012年10月-2014年10月来医院就诊的败血症新生儿40例,检测入院初及恢复期外周血SAA、CD64、PCT及CRP,选取同期非感染新生儿40例和健康新生儿40例进行比较。结果治疗前败血症组新生儿SAA、CD64、PCT及CRP水平均明显高于非感染组和健康对照组(P<0.05);以SAA≥5.3 mg/L、CD64≥35MFI、PCT≥0.5μg/L、CRP≥8 mg/L为阳性标准,检测新生儿败血症的敏感性分别为85.71%、95.73%、94.42%、69.67%,特异性分别为80.00%、95.80%、84.69%、75.00%。结论 SAA、CD64及PCT均可对新生儿败血症的早期诊断和病情评估提高参考依据。
Objective To analyze the value of serum amylase A protein (SAA), neutrophil surface antigen CD64 and procalcitonin (PCT) in the early diagnosis of neonatal sepsis. Methods Forty newborns with septicemia who visited the hospital from October 2012 to October 2014 were retrospectively analyzed. SAA, CD64, PCT and CRP in peripheral blood were detected at admission and convalescence. Forty non-infected newborns and healthy freshmen 40 cases were compared. Results The levels of SAA, CD64, PCT and CRP in neonates with pre-treatment sepsis were significantly higher than those in non-infected and healthy controls (P <0.05). SAA≥5.3 mg / L, CD64≥35 MFI, PCT≥0.5 μg / L , CRP≥8 mg / L as the positive standard. The sensitivity of detecting neonatal sepsis were 85.71%, 95.73%, 94.42% and 69.67% respectively, and the specificity was 80.00%, 95.80%, 84.69% and 75.00% respectively. Conclusion Both SAA, CD64 and PCT can improve the early diagnosis and assessment of neonatal sepsis.