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过去硒被认为是毒剂,50年代以后才被视为必需的微量元素,60年代以后,通过流行病学调查和动物实验始逐渐证实其抗癌作用。目前已知,硒是谷胱甘肽过氧化物酶(GSH-Px)的必需成分;而GSH-Px为肝内重要的抗氧化酶,能抑制过氧化反应,分解过氧化物,清除自由基,从而修复膜分子的损伤。因此,硒与肝病的关系日益受到重视。
In the past, selenium was considered as a toxicant and was considered as an essential trace element after the 1950s. Since the 1960s, selenium has been gradually confirmed by epidemiological investigations and animal experiments. It is known that selenium is an essential component of glutathione peroxidase (GSH-Px); and GSH-Px is an important antioxidant enzyme in the liver, which can inhibit peroxidation, decompose peroxides and scavenge free radicals , Thus repairing the damage of membrane molecule. Therefore, the relationship between selenium and liver disease is receiving more and more attention.