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目的 测定 5 4例 2型糖尿病患者和 34例健康正常人的血清超氧化物歧化酶 (SOD)、脂质过氧化物 (LPO)的最终产物丙二醛 (MDA)的水平。方法 采用黄嘌呤氧化酶法和硫代巴比妥的化学方法分别测定血清内的SOD和MDA含量。结果 ( 1) 2型糖尿病组血清SOD水平明显低于正常对照组 ,2型糖尿病组血清中的MDA含量高于正常对照组 ,二者差异均非常显著 (P <0 .0 1)。 ( 2 ) 2型糖尿病人中有慢性并发症组与无并发症组的血清SOD和MDA比较差异均有显著性。结论 提示 2型糖尿病患者血清抗氧化酶活性下降从而降低了清除自由基的能力 ,血清MDA含量的升高又间接反映出细胞损伤的程度。提示糖尿病及其并发症的发生可能与机体内氧自由基增多有关。
Objective To determine the level of malondialdehyde (MDA), the final product of serum superoxide dismutase (SOD) and lipid peroxides (LPO) in 54 type 2 diabetic patients and 34 healthy controls. Methods The contents of SOD and MDA in serum were determined by xanthine oxidase method and thiobarbital method. Results (1) The level of serum SOD in type 2 diabetes mellitus group was significantly lower than that in normal control group. The level of serum MDA in type 2 diabetes mellitus group was higher than that in normal control group (P <0.01). (2) There was significant difference in the serum SOD and MDA between chronic complication group and non-complication group in type 2 diabetes mellitus. Conclusions These results suggest that the serum antioxidant enzyme activity in type 2 diabetic patients decreases and thus reduces the ability of scavenging free radicals. The increase of serum MDA level indirectly reflects the degree of cell injury. Prompted the occurrence of diabetes and its complications may be related to increased body oxygen free radicals.