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近年来，随着辅助生殖技术的不断发展，冻融胚胎移植（frozen-thawed embryo transfer，FET）周期数不断增多，而激素替代疗法（hormone replacement therapy，HRT）是FET周期准备子宫内膜的主要方法之一。HRT-FET周期中雌、孕激素的暴露时间及血清雌、孕激素水平是否影响FET的成功率？是否可以以此为切入点，改善FET的治疗结局？本文对此进行了综述。在HRT-FET周期，给予孕激素前过短时间的雌激素暴露可能增加早期流产率，血清雌激素水平与治疗结局无相关性。胚胎移植前孕激素的暴露时间影响治疗结局，胚胎移植日血清孕激素水平是持续妊娠和活产的独立预后因素。“,”With the continuous development of assisted reproductive technology recently, frozen-thawed embryo transfer (FET) cycles are increasing, and hormone replacement therapy (HRT) is one of the main methods for preparing endometrium in FET cycles. Do the exposure time of estrogen and progesterone and the levels of serum estrogen and progesterone affect the success rate of FET? Can we use this as an entry point to improve the treatment outcome of FET? This article reviews papers in this field. In the HRT-FET cycle, short-term estrogen exposure before progestin administration might increase early miscarriage rate, and serum estrogen levels are not related to treatment outcome. The progesterone exposure time before embryo transfer affects the outcome of FET. The serum progesterone level on the day of embryo transfer is an independent prognostic factor for ongoing pregnancy and live birth.