双磷酸酯可抑制破骨细胞活性,从而对某些疾病引起的骨吸收增加有保护作用。动物实验与临床试验证实,早期用氯膦酸酯治疗可降低乳癌病变转移至骨的发生率。本研究主要评定该药对乳癌病变转移的抑制作用。对象为乳癌患者302例,肿瘤临床分期为T1,T2,T3或T4,组织学分期为N0,N... Bisphosphonates can inhibit the activity of osteoclasts and thus have a protective effect on increased bone resorption caused by certain diseases. Animal experiments and clinical trials have confirmed that early treatment with clodronate can reduce the incidence of breast cancer metastases to bone. This study evaluated the inhibitory effect of this drug on the metastasis of breast cancer. The subjects were 302 cases of breast cancer patients, clinical stage of the tumor was T1, T2, T3 or T4, histological stage was N0, N...