收集３６例石英粉尘作业工人肺癌（石英肺癌）的组织石蜡包埋物，提取其 Ｄ Ｎ Ａ，对 ｐ５３基因和 Ｋｒａｓ 基因进行了 Ｐ Ｃ Ｒ Ｓ Ｓ Ｃ Ｐ、 Ｐ Ｃ Ｒ Ｒ Ｆ Ｌ Ｐ及 Ｄ Ｎ Ａ 测序分析，发现具有完全有别于普通肺癌的特异基因突变谱。小细胞肺癌的 ｐ５３基因突变多发于第８外显子，腺癌的 ｐ５３基因突变率高。石英肺癌的 Ｋｒａｓ 基因突变未见一例发生于普通肺癌突变热点区第１２密码子上，相反发现多处非热点区突变，突变类型以 Ｇ→ Ｃ 突变为主。 36 cases of quartz dust workers lung cancer (quartz lung cancer) tissue paraffin embedding, extraction of its D N A, the p53 gene and K  ras genes were P C R S S C P, P C R R F L P and D N A sequencing analysis found that there is completely different from the common lung cancer-specific gene mutation spectrum. Small cell lung cancer p53 gene mutations occur in exon 8, adenocarcinoma of the p53 gene mutation rate. There was no case of K-ras mutation in quartz lung cancer, which occurred on the 12th codon in the hot spot of common lung cancer mutation. On the contrary, many non-hot spot mutations were found, and the mutation type was G → C mutation.