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我院曾用硬膜外注射小量吗啡方法,治疗12例晚期癌顽固性疼痛病人,现报告如下: 方法:本组病人,均系反复用镇痛药而不能长期止痛,并在用此法前至少4小时没有用任何镇痛药者。穿刺体位不限,但尽可能以疼痛部位为中心,选择相应神经支配节段脊椎间隙为穿刺点,常规进行硬脊膜外穿刺,置入导管,妥善固定。由导管缓慢注入含有2mg吗啡的10ml生理盐水溶液。注药后观察15～30分钟,无不良反应时,将硬膜外导管连接之针头装入带盖无菌小瓶内保存以备再用。操作前不需禁食、输液等,可每日到门诊或在家内注药。本组全部留置硬膜外导管,最长留置38天,平均留管16天。一般每日注药1次。本组12例病人共注射吗啡188人次。效果:所有病例均在注入吗啡后2～5分钟出现止痛作用,10～15分钟效果达到高峰,持续时间为12～50小时(平均22.7小时)。用药后所有病例均获不同程度的止痛效果,其中达到完全止痛者8例。另
In our hospital, we used epidural injection of small doses of morphine to treat 12 patients with advanced cancer with intractable pain. The current report is as follows: Method: Patients in this group were repeatedly treated with analgesics but could not be long-term analgesic, and used this method. No analgesics were used before at least 4 hours. The puncture position is not limited, but as far as possible the pain site as the center, select the corresponding innervation segment of the spinal space as a puncture point, routine spinal dural puncture, catheter placement, properly fixed. From the catheter, 10 ml of physiological saline solution containing 2 mg of morphine was slowly injected. After 15 to 30 minutes after the injection, no adverse reactions were observed. The epidural catheter-connected needles were stored in sterile vials with lids for reuse. There is no need for fasting, infusion, etc. before the operation. You can go to the outpatient clinic or do injection at home every day. In this group, all epidural catheters were indwelled and left for a maximum of 38 days. The average stayed for 16 days. General daily injections. This group of 12 patients were given a total of 188 morphine injections. Effects: All cases were analgesic 2 to 5 minutes after morphine injection, peaked at 10 to 15 minutes, and lasted for 12 to 50 hours (22.7 hours on average). All the patients received different degrees of analgesic effect after treatment, among which 8 cases achieved complete analgesia. another