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目的:比较肝切除并微波消融术与经肝动脉化疗栓塞术(TACE)治疗多发性肝癌的疗效方法:回顾性分析本科2007年1月至2008年8月收治的61例多发性肝癌患者,其中28例行肝切除并微波消融术(肝切除组),33例行TACE治疗(TACE组)。治疗后所有患者随访,Kaplan-Meier法分析组间生存差异。结果:两组患者均无住院期间死亡。肝切除组术后2个月AFP下降较TACE组明显(P<0.01)。肝切除组的1、2、3年生存率分别为75%、57.1%、35.7%,中位生存期26.5个月,显著高于TACE组的69.7%、30.3%、12.1%及18个月(P<0.05)。结论:对可耐受手术的多发性肝癌患者,肝切除并微波消融术安全有效,相对TACE能进一步提高患者3年生存率。
Objective: To compare the efficacy of hepatectomy with microwave ablation and transcatheter arterial chemoembolization (TACE) in the treatment of multiple liver cancer: a retrospective analysis of 61 patients with multiple liver cancer admitted to our hospital from January 2007 to August 2008, of which Twenty-eight patients underwent hepatectomy and microwave ablation (hepatectomy group) and 33 TACE patients (TACE group). All patients were followed up after treatment, Kaplan-Meier analysis of survival differences between groups. Results: There were no deaths during hospitalization in both groups. The decrease of AFP in hepatectomy group was more significant than that in TACE group 2 months after operation (P <0.01). The 1, 2, 3-year survival rates of hepatectomy group were 75%, 57.1%, 35.7%, respectively. The median survival time was 26.5 months, significantly higher than 69.7%, 30.3%, 12.1% and 18 months P <0.05). Conclusions: Hepatectomy and microwave ablation are safe and effective for patients with multiple liver cancer who can tolerate surgery. TACE can further improve the 3-year survival rate of patients.