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急性播散性脑脊髓炎(acute disseminated encephalomyelitis,ADEM)是一种广泛累及中枢神经系统(脑和脊髓)白质的急性炎性反应,以非对称多灶性或弥漫性脱髓鞘病灶为主要病理特征。ADEM临床表现多样,呈急性或亚急性起病,是儿童最常见的获得性脑白质病。本研究总结分析了3例昆明医科大学第一附属医院收治的ADEM患儿的临床特点、辅助检查、治疗、预后等资料,以期提高对ADEM的认识,现报告如下。1资料和方法1.1一般资料2015年10月1日至2016年3月1日昆明医科大学第一附属医院儿科收治ADEM患儿3例,其中1例为女孩(12岁);2例为男孩(分别为10岁和13岁),发病至就诊时间为4~7d。3例患儿既往体健,起病前无疫苗接种及特殊物品接触史,否认高热惊厥及癫疒间等病史。
Acute disseminated encephalomyelitis (ADEM) is an acute inflammatory reaction that widely affects the white matter in the central nervous system (brain and spinal cord). Asymptomatic multifocal or diffuse demyelinating lesions are the main pathological feature. ADEM clinical manifestations of various acute or subacute onset, is the most common children with acquired leukoencephalopathy. This study summarizes the three cases of ADEM children admitted to the First Affiliated Hospital of Kunming Medical University clinical features, auxiliary examination, treatment, prognosis and other information, in order to improve awareness of ADEM, are as follows. 1 Materials and Methods 1.1 General Information October 1, 2015 to March 1, 2016 First Affiliated Hospital of Kunming Medical University pediatric ADEM children treated 3 cases, of which 1 case was a girl (12 years); 2 cases were boys Respectively, 10 years old and 13 years old), onset to treatment time is 4 ~ 7d. 3 cases of children with previous health, before the onset of vaccination and contact with special articles history, denied the history of epilepsy such as febrile seizures.