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目的 研究血管内皮生长因子 (VEGF)在乳腺癌的发生及判断预后方面的意义。方法 应用S P免疫组化染色法检测VEGF在乳腺良恶性病变中的表达。结果 乳腺癌VEGF表达阳性率 (72 .5 % )高于乳腺良性病变 (2 /8) ,二者间差异具有显著性 (P <0 .0 5 )。 40例乳腺癌中 ,淋巴结转移组VEGF阳性表达 (19/ 2 1)高于无淋巴结转移组(12 / 19) ,二者差异具有显著性 (P <0 .0 5 )。结论 VEGF在乳腺癌发生及判断预后方面具有重要意义。
Objective To study the significance of vascular endothelial growth factor (VEGF) in the occurrence and prognosis of breast cancer. Methods The expression of VEGF in benign and malignant breast lesions was detected by SP immunohistochemical staining. Results The positive rate of VEGF expression in breast cancer (72.5%) was higher than that in benign breast lesions (2/8). The difference between the two was significant (P < 0.05). In 40 cases of breast cancer, the positive expression of VEGF in lymph node metastasis group (19/21) was higher than that in no lymph node metastasis group (12/19), and the difference was significant (P < 0.05). Conclusion VEGF plays an important role in the occurrence of breast cancer and its prognosis.