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蛋白尿是肾小球疾病最常见的表现。遗传性疾病如先天性肾病综合征或获得性肾小球疾病如微小病变肾病、膜性肾病、膜增生性肾炎均以大量蛋白尿为典型表现。人们早已认识到蛋白尿的发生与肾小球滤过屏障的异常有密切关系。肾小球滤过屏障包括三层 :内皮细胞孔、肾小球基膜 (ＧＢ
Proteinuria is the most common manifestation of glomerular disease. Genetic diseases such as congenital nephrotic syndrome or acquired glomerular diseases such as minimal change nephropathy, membranous nephropathy, membranous proliferative nephritis are a large number of proteinuria as a typical manifestation. It has long been recognized that the occurrence of proteinuria and glomerular filtration barrier abnormalities are closely related. The glomerular filtration barrier consists of three layers: endothelial cell pores, glomerular basement membrane (GB