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目的:观察枸橼酸透析液对维持性透析患者瘙痒症状、炎症指标的影响。方法:从高安市中医院血透室进行规律血透的92例患者,拟入选病例50例,随机数字法分为枸橼酸组17例,普通组17例,针灸组(普通透析液+针灸治疗)16例。观察患者瘙痒面积、瘙痒程度、皮损形态的影响等疗效指标;生化指标(ESR、CRP及血常规、尿常规、肝肾功能)。结果:(1)治疗后枸橼酸组患者瘙痒症状、体征及实验室结果有明显改善,对比普通组,有明显统计学意义(P<0.01);(2)治疗后枸橼酸组患者症状、体征及实验室检查对比针灸组有差异,有统计学意义(P<0.05);(3)治疗后枸橼酸组患者治疗后瘙痒总积分比针灸组有差异,有统计学意义(P<0.05);(4)枸橼酸透析液组患者治疗后瘙痒总积分与普通透析液组比较,有差异,有明显统计学意义(P<0.01);(5)通过临床观察发现三组未见明显不良反应。结论:(1)枸橼酸透析液可以减轻尿毒症患者的瘙痒不适;(2)枸橼酸透析液组缓解尿毒症患者瘙痒不适优于普通透析液组及针灸普通透析液加针灸治疗组。
Objective: To observe the effect of citrate dialysate on pruritus symptoms and inflammation in maintenance hemodialysis patients. Methods: A total of 92 cases of hemodialysis patients were randomly divided into citric acid group (n = 17), common group (n = 17), acupuncture group (general dialysis fluid + acupuncture Treatment) in 16 cases. To observe the curative effect of pruritus area, pruritus degree and the morphological changes of skin lesions; biochemical indexes (ESR, CRP, blood, urine, liver and kidney function). Results: (1) Symptoms and signs of pruritus and laboratory findings in citrate group were significantly improved after treatment compared with normal group (P <0.01); (2) Symptoms of citrate group (P <0.05). (3) The total score of pruritus in citrate group after treatment was significantly lower than that of acupuncture group (P <0.05), and the difference was statistically significant 0.05). (4) The total score of pruritus in citrate dialysate group was significantly different from that in dialysis group (P <0.01). (5) Obvious adverse reaction. Conclusions: (1) Citric acid dialysate can relieve pruritus and discomfort in patients with uremia; (2) Citric acid dialysate group relieves pruritus and discomfort in patients with uremia is better than ordinary dialysate group and acupuncture dialysis plus acupuncture group.