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目的:探讨双歧三联活菌胶囊联合瑞舒伐他汀对高脂血症患者血脂及肠道菌群的影响。方法:80例高脂血症患者随机分为观察组和对照组各40例。对照组予瑞舒伐他汀片10 mg,po qd;观察组在此基础上加用双歧三联活菌胶囊630 mg,po tid。两组疗程均为12周。观察两组治疗前后总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,及肠道菌群(双歧杆菌、乳酸杆菌、大肠埃希菌和粪肠球菌)变化,比较两组药品不良反应发生情况。结果:治疗12周后,两组TC、TG和LDL-C水平较前均明显下降,HDL-C水平明显上升(P<0.05或P<0.01),且治疗后观察组各项血脂指标均明显优于对照组(P<0.05)。两组双歧杆菌和乳酸杆菌、粪肠球菌数量较前明显上升,大肠埃希菌数量明显下降(P<0.05或P<0.01),且观察组变化幅度比对照组更明显(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双歧三联活菌胶囊联合瑞舒伐他汀治疗高脂血症患者的降脂疗效显著,安全性较好,与双歧三联活菌调节并纠正肠道微生态失衡,恢复肠道有益菌数量密切相关。
Objective: To investigate the effects of bifid triple viable capsule combined with rosuvastatin on blood lipids and intestinal microflora in patients with hyperlipidemia. Methods: 80 cases of hyperlipidemia were randomly divided into observation group and control group of 40 cases. The control group was given rosuvastatin tablets 10 mg, po qd; observation group on this basis with bifidobacterium triple viable capsule 630 mg, po tid. The two groups were treated for 12 weeks. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and intestinal microflora (Bifidobacterium , Lactobacillus, Escherichia coli and Enterococcus faecalis) were compared, and the adverse reactions of two groups were compared. Results: After 12 weeks of treatment, TC, TG and LDL-C levels decreased significantly in both groups, HDL-C level increased significantly (P <0.05 or P <0.01) Better than the control group (P <0.05). The numbers of Bifidobacterium, Lactobacillus and Enterococcus faecalis in two groups increased significantly compared with those in the previous two groups, the number of Escherichia coli decreased significantly (P <0.05 or P <0.01), and the changes in observation group were more obvious than those in control group (P <0.05) . There was no significant difference between the two groups in the incidence of adverse drug reactions (P> 0.05). Conclusion: Bifid triple viable capsule combined with rosuvastatin treatment of patients with hyperlipidemia lipid-lowering effect of significant, safe, and Bifidobacterium triple viable bacteria regulate and correct intestinal microflora imbalance and restore beneficial intestinal bacteria The number is closely related.