论文部分内容阅读
作者用戊脘脒治疗一例热带利什曼病人,剂量为4毫克/公斤/天×9天,治疗后立即对一个皮肤结节进行活检,在电子显微镜下观察原虫形态的变化。发现变化最明显的部位是动基体-线粒体复合物。所有原虫的线粒体均极度胀大,占整个虫体的25～50%,线粒体的体壁一般很模糊,线粒体嵴消失。除5%原虫的动基体呈正常外,绝大多数原虫的动基体发生了变化,它原来厚而平行的环层崩解或由细纤丝组成的网状复合物,但不渗入到崩解了的线粒体范围内,故两者有明显的界线。此外,尚可见到从正常到崩解变化过程中的动基体,先是环层变薄,继则有一端或两端开始崩解,最后全部崩解。鞭毛袋扩张,并含有同质性物质,在袋内可见到数量众多的大小不等且边缘具有双层膜的小体,相
The authors used pentamidine to treat one case of tropical Leishmania at a dose of 4 mg / kg / day x 9 days. A skin nodule was biopsied immediately after treatment and morphological changes were observed under an electron microscope. Found that the most obvious part of the change is dynamic matrix - mitochondrial complex. Mitochondria of all protozoa are extremely swollen, accounting for 25 to 50% of the entire body, mitochondrial body wall is generally very blurred mitochondrial cristae disappeared. In addition to 5% protozoan moving body was normal, the vast majority of protozoa moving body has changed, it originally thick and parallel disintegration of the ring layer or by the fibril network composition, but does not penetrate into the disintegration The scope of the mitochondria, so the two have obvious boundaries. In addition, we can still see the dynamic matrix changing from normal to disintegration. First, the ring layer becomes thinner, and then one or both ends begin to disintegrate, finally all disintegrate. Flagella bags expand, and contain homogenous substances, visible in the pouch in numerous sizes and brims with bilayer membranes