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目的：探讨缺血再灌注损伤大鼠采用七氟醚预处理后的神经保护作用及临床价值。方法39只健康雄性 SD 大鼠，根据处理方式不同分为假手术组、损伤组及七氟醚组，每组13只；损伤组和七氟醚组大鼠均行大脑中动脉阻闭模型（MCAO）处理，七氟醚组大鼠制作 MCAO 模型前给予七氟醚预处理，假手术组只进行右侧颈总动脉和颈外动脉结扎处理；对比分析3组大鼠的神经功能缺陷评分情况及大鼠脑组织内肿瘤坏死因子_α（TNF_α）和白细胞介素_1β（IL_1β）蛋白的含量。结果假手术组大鼠的神经功能损伤评分均为0分；损伤组1只（7．7%）大鼠为4分、7只（53．8%）大鼠为3分、5只（38．5%）大鼠为2分；七氟醚组3只（23．1%）大鼠为3分、5只（38．5%）大鼠为2分、5只（38．5%）大鼠为1分。损伤组大鼠的脑组织 TNF_α和 IL_1β蛋白水平明显高于假手术组和七氟醚组，而七氟醚组大鼠的脑组织 TNF_α和 IL_1β蛋白水平略高于假手术组；3组相比较，差异有统计学意义（P ＜0．05）。结论局灶性脑缺血再灌注损伤采用七氟醚预处理，起到了延迟性保护的作用，其机制与 TNF_α和IL_1β等炎性因子蛋白含量降低有关。“,”Objective To study the neuroprotective effect and clinical value of Sevoflurane in rats of ischemia reper_fusion injury. Methods 39 healthy and male SD rats were selected;the subjects were divided into sham_operation group,inju_ry group and Sevoflurane group,13 cases each group. The injury group and Sevoflurane group adopted MCAO;for Sevoflurane group,Sevoflurane was pre_conditioned;the sham_operation group adopted the ligation processing in the right common carotid artery and external carotid artery. The evaluation score of nerve function defect and content of TNF_α and IL_1β for three groups was compared. Results The evaluation score of nerve function defect for sham_operation group was 0 score;the injury group had 1 case with 4 scores(7. 7% ),7 cases with 3 scores(53. 8% )and 5 cases with 2 scores(38. 5% );Sevoflurane group had 3 cases with 3 scores(23. 1% ),5 cases with 2 scores(38. 5% )and 5 cases with 1 score(38. 5% );the content of TNF_α and IL_1β for injury group was higher than sham_operation group and Sevoflurane group;the content of TNF_α and IL_1β for Sevoflurane group was higher than sham_operation group(P < 0. 05). Conclusion For rats of focal ischemia reperfusion injury,the preconditioning of Sevoflurane has a protection effect of which its mechanism may be correlated with the decreasing TNF_α and IL_1β content.