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目的:观察顺铂联合5-氟尿嘧啶热灌注化疗治疗恶性胸腹水的疗效。方法:将48例恶性胸腹水患者给予胸腹腔中心静脉导管闭式引流胸腹水,并通过HGGZ-102体腔热灌注系统将顺铂和5-氟尿嘧啶注入胸腹腔,连续灌注2周,每周1次,4周后评定疗效。结果:顺铂联合5-氟尿嘧啶热灌注化疗对恶性胸腹水的有效率为77.1%,以白细胞减少和消化道反应为主要不适。结论:顺铂联合5-氟尿嘧啶热灌注化疗治疗恶性胸腹水近期疗效肯定,胸腹腔中心静脉导管置管操作简单安全,不良反应少。
Objective: To observe the efficacy of cisplatin combined with 5-Fluorouracil hyperthermic chemotherapy in the treatment of malignant pleural effusion. Methods: Forty-eight patients with malignant ascites and pleural effusion were given thoracic and abdominal central venous catheters for drainage of hydrothorax and ascites, and cisplatin and 5-fluorouracil were injected into the abdominal cavity through HGGZ-102 body cavity perfusion system. The rats were continuously perfused for 2 weeks and once per week , 4 weeks after the assessment of efficacy. Results: The effective rate of cisplatin combined with 5-Fluorouracil hyperthermic chemotherapy on malignant pleural effusion was 77.1%. The main discomfort was leukopenia and gastrointestinal reaction. Conclusion: Cisplatin combined with 5-fluorouracil hyperthermic chemotherapy in the treatment of malignant pleural and ascitic effusion has a positive curative effect. Catheterization of thoracic and abdominal central venous catheters is simple and safe with few adverse reactions.