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葡萄胎(HM)是异常人类妊娠,以绒毛滋养细胞增生、间质水肿,同时缺乏胚胎发育或者异常的胚胎发育为特征,是一种滋养细胞疾病(GTD)。超声的广泛使用使早期诊断和处理葡萄胎成为可能,但其确诊依据仍是组织学诊断;葡萄胎治疗有一定难度,且葡萄胎特别是复发性葡萄胎的预后不理想。葡萄胎的发生机制尚不明确,细胞遗传学研究发现葡萄胎组织染色体核型异常和基因印迹错误。最近对葡萄胎患者基因方面的研究发现,NLRP7基因与复发性葡萄胎存在相关性。就葡萄胎及其与NLRP7基因的研究进展综述。
Mole (HM), an abnormal human pregnancy, is a trophoblastic disease (GTD) characterized by villous trophoblastic proliferation, interstitial edema, and lack of embryonic development or abnormal embryonic development. The widespread use of ultrasound makes early diagnosis and treatment of hydatidiform mole possible, but its diagnosis is still based on histological diagnosis; hydatidiform mole has a certain degree of difficulty, and hydatidiform mole, especially recurrent hydatidiform mole prognosis is not ideal. The pathogenesis of hydatidiform mole is not clear, cytogenetics study revealed mole abnormalities in chromosome structure and gene imprinting error. Recent studies on the genetics of hydatidiform moles revealed that there is a correlation between the NLRP7 gene and recurrent hydatidiform mole. A review on the research progress of hydatidiform mole and NLRP7 gene.