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目的：评价硝酸甘油（ＮＧ）对充血性心力衰竭患者血浆内皮素的影响。方法：应用放射免疫法测定３２例充血性心力衰竭患者和１７例健康人血浆内皮素浓度。充血性心力衰竭组含１７例冠心病和１５例非冠心病患者。观测ＮＧ静脉滴注前后内皮素、心率和血压的动态变化。结果：充血性心力衰竭组内皮素浓度为９３．８６±１３．４８ｐｇ／ｍｌ，较对照组（３８．１７±１７．２４ｐｇ／ｍｌ）显著升高（Ｐ＜０．００１）。内皮素升高的程度与充血性心力衰竭的严重程度平行；与充血性心力衰竭的病因无关。ＮＧ静脉滴注后充血性心力衰竭患者内皮素浓度（６６．１８±１１．１３ｐｇ／ｍｌ）显著降低（Ｐ＜０．００１）；心功能Ⅱ级、Ⅲ级、Ⅳ级者分别降低２６％、２９％、３４％。血压和心率无明显变化。结论：ＮＧ不仅能改善充血性心力衰竭患者血液动力学紊乱，而且能显著降低内皮素的血浆浓度。
Objective: To evaluate the effect of nitroglycerin (NG) on plasma endothelin in patients with congestive heart failure. Methods: The plasma endothelin concentrations in 32 patients with congestive heart failure and 17 healthy individuals were determined by radioimmunoassay. Congestive heart failure group contains 17 cases of coronary heart disease and 15 cases of non-coronary heart disease patients. The changes of endothelin, heart rate and blood pressure before and after NG intravenous drip were observed. Results: The endothelin concentration of congestive heart failure group was 93.86 ± 13.48pg / ml, which was significantly higher than that of the control group (38.17 ± 17.24pg / ml) (P <0.001). The level of endothelin increases in parallel with the severity of congestive heart failure; it is not associated with the etiology of congestive heart failure. The level of endothelin (66.18 ± 11.13 pg / ml) in patients with congestive heart failure after NG intravenous drip was significantly decreased (P <0.001), and those in patients with grade Ⅱ, Ⅲ and Ⅳ of heart function decreased by 26% 29%, 34%. No significant changes in blood pressure and heart rate. Conclusion: NG can not only improve hemodynamic disturbance in patients with congestive heart failure, but also significantly reduce the plasma concentration of endothelin.