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采用放射免疫法对生化肝功能正常的１９８例ＨＢｓＡｇ无症状携带者、２２例无症状而有胆道疾病史者和２１３例正常对照的血清甘胆酸（ＣＧ）和ＨＢＶ标记物进行检测并对结果进行统计分析。结果：①ＨＢｓＡｇ无症状携带者血清ＣＧ和有胆道疾患史组的异常率（分别为７６．２６％、７２．７２％）明显高于对照组（０．９８％）（μ分别为３．３７和１２．０５，Ｐ均＜０．０５）；大三阳组（９２．５５％）明显高于小三阳组（６１．５３％）（μ＝５．１２，Ｐ＜０．０５）；②大三阳组（９１．９６±３５．４８ｍｇ／Ｌ）明显高于小三阳组（３３．０８±１２．４６ｍｇ／Ｌ）（Ｑ＝３２．０３，Ｐ＜０．０５）。结果表明：ＨＢｓＡｇ无症状携带者肝脏比正常人群更易受到早期损害；大三阳者肝脏早期损害程度比小三阳更为严重，且发生异常更为常见。
198 cases of HBsAg asymptomatic carriers with normal biochemical liver function, 22 cases of asymptomatic biliary tract disease and 213 cases of normal control serum glycocholic acid (CG) and HBV markers were detected by radioimmunoassay and the results conduct statistical analysis. Results: (1) The abnormal rates of serum CG and history of biliary tract disease in HBsAg asymptomatic carriers were 76.26% and 72.72%, respectively, significantly higher than those in the control group (0.98% and 3.37, respectively 12.05, P <0.05); Dasanyang group (92.55%) was significantly higher than that of Xiaosanyang group (61.53%) (μ = 5.12, P <0.05) Sanyang group (91.96 ± 35.48mg / L) was significantly higher than the Sanyang group (33.08 ± 12.46mg / L) (Q = 32.03, P <0.05). The results showed that the liver of HBsAg asymptomatic carriers were more likely to be damaged early than the normal population. The degree of early liver damage in HBsAg was more serious than that of Xiaoyangyangyang, and the abnormality was more common.